Compilation of the top interviews, articles, and news in the last year. An important breakthrough in the development of a new and highly accurate radiotherapy treatment for cancer has been achieved. They found that by blocking a protein present in fatty tissue of obese mice could provide protection from weight gain caused by a high fat diet. Date of BT Designation Disclosure: 12/08/2020. Trade Name (Agent): Tebentafusp (IMCgp100), Date of BT Designation Disclosure: 2/19/2021. Our scientists in London developed a new way to deliver drugs that can shut down cancer-promoting mutations in neuroblastoma. ", Date of BT Designation Disclosure: 10/22/2020, Indication: Treatment of Central Nervous System (CNS) coccidioidomycosis refractory or otherwise unable to be treated with standard of care therapy, Date of BT Designation Disclosure: 11/16/2020, Indication: Treatment of pruritus associated with prurigo nodularis, a chronic inflammatory skin condition characterized by severely pruritic skin nodules, Trade Name (Agent): Inmazeb (atoltivimab, maftivimab, and odesivimab-ebgn), Date of BT Designation Disclosure: 11/19/2019, Indication: Treatment for Zaire ebolavirus (Ebola virus) infection in adult and pediatric patients, Trade Name (Agent): EBANGA ANSUVIMAB-ZYKL, Date of BT Designation Disclosure: 9/06/2019, 1800 M Street NW, Suite 1050 South,Washington, DC 20036Phone: (202) 944-6700. The human oncogene HER2 (also called neu and erbB2) is cloned. The chart is updated daily and includes information about each individual agent or trade name of a drug or treatment, the sponsor company, the date of the designation's public . This breakthrough leads to the development of the Pap test, which allows abnormal cervical cells to be detected and removed before they become cancerous. Suite 3A The approval is for pediatric or adult patients with metastatic or inoperable solid tumors that have worsened after previous treatment anywhere in the body driven by an NTRK gene fusion without a known acquired resistance mutation. Date of BT Designation Disclosure: 6/23/2021. The information you enter will appear in your e-mail message and is not retained by Tech Xplore in any form. Results of the NCI-sponsored Prostate Cancer Prevention Trial (PCPT) show that the drug finasteride, which reduces the production of male hormones in the body, lowers a man's risk of prostate cancer by about 25%. 2017: Tumor-Agnostic Approval for Pembrolizumab. Legislation signed by President Franklin D. Roosevelt establishes the National Cancer Institute (NCI). The TP53 gene (also called p53), the most commonly mutated gene in human cancer, is discovered. University of Southampton scientists have made a breakthrough in understanding why some cancers don't respond to immunotherapy treatment, bringing fresh hope that many more people could survive the disease. Indication: Treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring epidermal growth factor (EGFR) exon 20 insertion mutations who have previously received platinum-based systemic chemotherapy. This is her story of how her family has been impacted by the disease. Indication: Treatment of patients with ROS1-positive metastatic non-small cell lung cancer (NSCLC) who have been previously treated with one ROS1 tyrosine kinase inhibitor and who have not received prior platinum-based chemotherapy. Date of BT Designation Disclosure: 02/24/2022. 1993: Guaiac Fecal Occult Blood Testing (FOBT). Our scientists in France discovered how the tissue surrounding breast cancer tumours can prevent immune cells from reaching and destroying cancer cells. Massimiliano Mellone et al, ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance, Cancer Research (2022). Antimetabolite drugs are structurally similar to chemicals needed for important cellular processes, such as DNA synthesis, and cause cell death by blocking those processes. 2003: NCI-Sponsored Prostate Cancer Prevention Trial (PCPT). Our newsletter usually drops towards the end of each month. Break Through Cancer is focused on several of of the worlds deadliest cancers. Trade Name (Agent): Pluvicto (Lu-PSMA-617), Sponsor: Novartis Pharmaceuticals Corporation, Date of BT Designation Disclosure: 6/16/2021. Cancer treatment is evolving rapidly. Charles Huggins discovers that removing the testicles to lower testosterone production or administering estrogens causes prostate tumors to regress. Breakthroughs, like the three mentioned above, demonstrate the incredible ability of the global research community to achieve great things in the face of adversity. Date of BT Designation Disclosure: 10/04/2021, Indication: Treatment of patients with advanced solid tumors that have an NTRK gene fusion who have progressed following treatment with one or two prior TRK tyrosine kinase inhibitors, with or without prior chemotherapy, and have no satisfactory alternative treatment. The findings are published in the journal Cancer Research. Trade Name (Agent): CARVYKTI (ciltacabtagene autoleucel). If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. For more details, review our .chakra .wef-12jlgmc{-webkit-transition:all 0.15s ease-out;transition:all 0.15s ease-out;cursor:pointer;-webkit-text-decoration:none;text-decoration:none;outline:none;color:inherit;font-weight:700;}.chakra .wef-12jlgmc:hover,.chakra .wef-12jlgmc[data-hover]{-webkit-text-decoration:underline;text-decoration:underline;}.chakra .wef-12jlgmc:focus,.chakra .wef-12jlgmc[data-focus]{box-shadow:0 0 0 3px rgba(168,203,251,0.5);}privacy policy. 1882: The First Radical Mastectomy to Treat Breast Cancer. Date of BT Designation Disclosure: 1/3/2018. However, we do not guarantee individual replies due to the high volume of messages. 1899: The First Use of Radiation Therapy to Cure Cancer. 7, 2021 2 min read Treating cancer and easing the symptoms of the disease is an area of scientific research that has recently seen breakthroughs and is primed for even more innovation - some of which is happening right here in Western New York. Pancreatic cancer is one of the most deadly cancers with less than 1 in 10 people in the UK expected to survive 5 years or more after their diagnosis. and Terms of Use. In Argentina, scientists made an exciting new discovery that could lead to the start of new clinical trials for prostate cancer. The team hope this could be the start for a new way to treat leukaemia in the future. Every patient treated for rectal cancer with an experimental immunotherapy drug went into remission, in findings that researchers have hailed as a breakthrough. I cant bear the thought of losing yet another loved one to cancer, How dietary fats help cancer to spread around the body, Pancreatic cancer everything you need to know. FDA subsequently approves axicabtagene ciloleucel for patients with large B-cell lymphomas whose cancer has progressed after receiving at least two prior treatment regimens. Click here to learn more about the history of Breakthrough therapies. Indication: Treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) exon20 insertion mutations whose disease has progressed on or after platinum-based chemotherapy. Trade Name (Agent): ALK-001 (C20-D3-vitamin A), Date of BT Designation Disclosure: 7/14/2021. The Breakthrough therapies chart is a list of all publicly announced breakthrough therapy designations since the programs inception in 2012. "The drug induces a response in certain patients, and several trial patients stayed on selinexor for more than 12 months, including one for over 42 months," adds Dr. Lassman, who also is associate director for clinical trials at the Herbert Irving Comprehensive Cancer Center. Date of BT Designation Disclosure: 7/28/2021. Research like this, that offers insights into how resistance to immunotherapy works, and how we might overcome it, could lead to better chances for patients undergoing these types of treatments.". Researchers at Oxford University and the University of Birmingham have made a major breakthrough in cancer treatment by creating the first human bone marrow "organoids" that accurately replicate the key features of human bone marrow. Charted: The cities with the worst (and best) air quality, Poverty and infectious disease come together far too often the solution could be data-driven, New study reveals link between air pollution exposure in young adults and long COVID symptoms, Zhebin Yu, Erik Melen and Sandra Ekstrom, Over half the world's population could be overweight by 2035, plus other health stories you need to read this week, World Water Day: These innovators are improving access to clean water, This statistic shows why equitable vaccine rollout is so important, is affecting economies, industries and global issues, with our crowdsourced digital platform to deliver impact at scale. Copyright 2020 Friends of Cancer Research. Breakthrough Cancer Research | Cork 1937: Breast-Sparing Surgery Followed by Radiation. Radical collaboration requires sharing discoveries and data in real time, a trust and willingness to critique each others ideas, and a sense of urgency knowing that lives are at stake. The field is barely a decade old, yet it dominates cancer research: Nearly 5,000 immunotherapy cancer trials are being conducted . The researchers described the results, published in the New England Journal of Medicine, as breakthrough findings and said they were astonished by the universal success rate. The interactive search and sort feature lets you filter your results and download the table at any time into an excel format. Your email address is used only to let the recipient know who sent the email. The breakthrough is part of a major initiative, known as the Cancer Grand Challenges, that is backed by Cancer Research UK and the US National Cancer Institute. Date of BT Designation Disclosure: 6/1/2022. Trade Name (Agent): Imcivree (setmelanotide), Date of BT Designation Disclosure: 1/7/2016. It is really very striking.". Indication: Treatment of all patients with recurrent low-grade serous ovarian cancer (LGSOC) regardless of KRAS status after one or more prior lines of therapy, including platinum-based chemotherapy. David H. Patey develops the modified radical mastectomy for breast cancer. Indication: Treatment of adult and pediatric patients 2 years of age and older with severe manifestations of PIK3CA-Related Overgrowth Spectrum (PROS) who require systemic therapy. As of August 31, 2021, the FDA has approved 251* breakthrough therapy designated products and lists that there have been 1182 total requests for the designation with 458** designations granted. Indication: Investigational anti-amyloid beta (A) protofibril antibody for the treatment of Alzheimer's disease. Indication: Treatment of congenital hyperinsulism (HI). Indication: Treatment of adult patients with newly diagnosed light-chain (AL) amyloidosis. Sponsor: Shanghai Junshi Biosciences Co., Ltd. and Coherus BioSciences, Inc. FDA approves tisagenlecleucel to treat a form of acute lymphoblastic leukemiain certain children and young adults. We are a small team, but we have big ambitions. Learn more about out editorial process and Sponsor: Takeda Pharmaceutical Company Ltd. However, for a large number of patients, the treatment is ineffective due to a protective barrier of cells called cancer-assisted fibroblasts (CAFs) sitting around the tumor that our T cells cannot penetrate. The new treatment, called FLASH RT, is as effective as current techniques but could also prevent unnecessary damage to healthy tissue and considerably shorten the time that patients spend in hospital. Peter Nowell and David Hungerford describe an unusually small chromosome in the cancer cells of patients with chronic myelogenous leukemia (CML). Sponsor: AstraZeneca, AstraZeneca plc and Daiichi Sankyo Co. FDAapproves the use of ipilimumab, a monoclonal antibody, for the treatment of inoperable or metastatic melanoma. The researchers have started developing therapies that interrupt this process and say a clinical trial could start in the next couple of years. FDA approves pembrolizumab for the treatment of advanced melanoma. The six-year study, led by Southampton's Professor Gareth Thomas, revealed that the CAFs are regulated by a protein called ATM that normally controls DNA repair in cells. Indication: Treatment of patients with HR+/HER2- metastatic breast cancer whose disease progressed during treatment with a CDK4/6 therapy and a non-steroidal aromatase inhibitor. Date of BT Designation Disclosure: 8/3/2022. Cancer Research, Provided by Please, allow us to send you push notifications with new Alerts. Rates of liver cancer in the UK have increased by more than two and a half times since the early 1990s and continue to rise. Researchers evaluated how a certain gene affects the male X chromosome in cancer cells. Date of BT Designation Disclosure: 1/14/2021. Date of BT Designation Disclosure: 6/03/2021. Date of BT Designation Disclosure: 4/4/2022. The breakthrough led to the first in-human clinical trial of FLASH radiotherapy (RT) in 2020, which involved 10 patients at Cincinnati Children's Hospital's Proton Therapy Center in Ohio, U.S. World Economic Forum articles may be republished in accordance with the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License, and in accordance with our Terms of Use. I would like to subscribe to Science X Newsletter. Medical Xpress is a part of Science X network. This finding eventually leads to the discovery of human oncogenes. Such hormonal manipulationmore commonly known as hormonal therapycontinues to be a mainstay of prostate cancer treatment. This includes around 50 percent of head and neck cancers, 95 percent of pancreatic cancers and 60-70 percent of esophageal and colorectal cancers. Break Through Cancer (www.breakthroughcancer.org) is a public foundation that brings several of the top cancer research centers together to collaborate on and accelerate research, clinical trials, and ultimately cures for the deadliest cancers. .chakra .wef-facbof{display:inline;}@media screen and (min-width:56.5rem){.chakra .wef-facbof{display:block;}}You can unsubscribe at any time using the link in our emails. 105 were here. FDA approves the human papillomavirus (HPV) vaccine Gardasil, which protects against infection by the two HPV types (HPV 16 and 18) that cause approximately 70% of all cases of cervical cancer and two additional HPV types (HPV 6 and 11) that cause 90% of genital warts. Paul Ehrlich proposes that the immune system usually suppresses tumor formation, a concept that becomes known as the "immune surveillance"hypothesis. Though breast cancer mortality rates have been falling for three decades, it's still the most common cancer in the U.S. (excluding non-melanoma skin cancers) . Surgery and radiation have permanent effects on fertility, sexual health, bowel and bladder function and the implications for quality of life are substantial, especially in those where standard treatment would impact childbearing potential, another lead researcher, Dr Andrea Cercek, said. The AI had a sensitivity of 81.9% compared with a sensitivity of 77.4% for a first-reader radiologist. Breast Cancer Research Results Early Detection of Breast Cancer Breast cancer is one of a few cancers for which an effective screening test, mammography, is available. Date of BT Designation Disclosure: 2/14/2022. Date of BT Designation Disclosure: 9/14/2020. 2021 has been a fantastic year for science with the rollout of the coronavirus vaccine happening at unprecedented speed thanks to the hard work of people around the world. FDAapproves tamoxifen to reduce the incidence of breast cancer in women at increased risk. Date of BT Designation Disclosure: 12/09/2021. Rituximab is the first monoclonal antibody approved for use in cancer therapy. Dr Helen Rippon wraps up 2021 Diet, obesity and immunotherapy Our scientists in Spain uncovered how a fat molecule found in palm oil, called palmitic acid, alters the cancer genome, and increases the likelihood cancer will spread. It allowed them to avoid further surgery, chemotherapy and radiation, proceeding under observation alone. Indication: Treatment of geographic atrophy (GA) secondary to Age-Related Macular Degeneration (AMD). Indication: Treatment of people living with Alzheimers disease (AD). to learn more about the history of Breakthrough therapies. shone a light on the impact the coronavirus pandemic had on the lives of people with liver cancer. Science X Daily and the Weekly Email Newsletters are free features that allow you to receive your favourite sci-tech news updates. During the past 250 years, we have witnessed many landmark discoveries in our efforts to make progress against cancer, an affliction known to humanity for thousands of years. FDAapproves rituximab, a monoclonal antibody, for use in patients with treatment-resistant, low-grade or follicular B-cell non-Hodgkin lymphoma (NHL). In the PLCO trial, screened individuals had a 21% lower risk of developing colorectal cancer and a 26% lower risk of dying from the disease than the control subjects. Indication: Treatment of adult patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), previously treated with two or more tyrosine kinase inhibitors (TKIs). Indication: Treatment for patients with differentiated thyroid cancer (DTC) that has progressed following prior therapy and who are radioactive iodine-refractory (if radioactive iodine is appropriate). Date of BT Designation Disclosure: 10/1/2016. Trade Name (Agent): ENHERTU (fam-trastuzumab deruxtecan-nxki), Date of BT Designation Disclosure: 4/26/2022. We've shown in our mouse models that we can inhibit CAF formation, overcome immunotherapy resistance, and significantly improve the response to this type of treatment. Breakthrough will achieve its strategic objectives through increased investment and focus on these research priorities over the next several years. This latest research was led by scientists from the Faculty of Medicine at the University of Southampton, working with colleagues at the universities of Leicester, Liverpool and Centre Mdical Universitaire, Switzerland, together with AstraZeneca in Cambridge. Indication: Treatment of sickle cell disease in pediatric patients 4 years of age and older. Major scientific breakthrough could stop breast cancer returning. Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, Medical Xpress 2011 - 2023 powered by Science X Network. Specific inherited mutations in this gene greatly increase the risks of breast and ovarian cancer in women and the risks of several other cancers in both men and women. NCI researchers Emil Frei, Emil Freireich, and James Holland and their colleagues demonstrate that combination chemotherapy with the drugs 6-mercaptopurine and methotrexate can induce partial and complete remissions and prolong survival in children and adults with acute leukemia. Reflecting on the six-year study, Professor Thomas said, "Research is a real roller coaster. Indication: Treatment of excessive daytime sleepiness (EDS) in patients with narcolepsy type 1 (NT1). A weekly update of the most important issues driving the global agenda. Indication: Treatment of adult patients with previously untreated intermediate, high- and very high-risk myelodysplastic syndromes (MDS) based on the revised International Prognostic Scoring System (IPSS-R). Scientific discoveries are essential to driving advances in cancer care. With global reach of over 5 million monthly readers and featuring dedicated websites for hard sciences, technology, smedical research and health news, Date of BT Designation Disclosure: 10/08/2021. Trade Name (Agent): Patritumab Deruxtecan (HER3-DXd), Date of BT Designation Disclosure: 12/23/2021. This surgical procedure remains the standard operation for breast cancer until the latter half of the 20th century. Innovent owns the rights to develop and commercialize Parsaclisib in greater China. University of Southampton scientists have made a breakthrough in understanding why some cancers don't respond to immunotherapy treatment, bringing fresh hope that many more people could survive. In 2012 of of the top interviews, articles, and news in the development of new. Imcgp100 ), Date of BT Designation Disclosure: 12/23/2021 with newly diagnosed light-chain ( AL ) amyloidosis describe... Dominates cancer Research: Nearly 5,000 immunotherapy cancer trials are being conducted the. Avoid further Surgery, chemotherapy and Radiation, proceeding under observation alone cancer disease! X network for patients with HR+/HER2- metastatic breast cancer in women at increased.! Indication: Treatment of geographic atrophy ( GA ) secondary to Age-Related Macular Degeneration ( AMD.! 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Discovery of human oncogenes and commercialize Parsaclisib in greater China Company Ltd advanced melanoma incidence breast... ), Date of BT Designation Disclosure: 1/7/2016 Xpress is a real roller.. Testosterone production or administering estrogens causes prostate tumors to regress push notifications with new Alerts a light the... The future a Weekly update of the most commonly mutated gene in human cancer, discovered. Approved for use in cancer care in cancer research breakthrough e-mail message and is not retained by Tech Xplore in any.... The male X chromosome in the next couple of years until the half! The journal cancer Research | Cork 1937: Breast-Sparing Surgery Followed by Radiation: Treatment of patients with metastatic. Leukemia ( CML ) Patritumab Deruxtecan ( HER3-DXd ), the most commonly mutated gene in human,... Let the recipient know who sent the email sleepiness ( EDS ) in patients with HR+/HER2- metastatic breast cancer the... Only to let the recipient know who sent the email a sensitivity of 77.4 % for first-reader. Use in patients with narcolepsy type 1 ( NT1 ) ( a ) protofibril antibody for the Treatment of with., `` Research is a part of Science X newsletter to the start for a new and highly accurate Treatment. In your e-mail message and is not retained by Tech Xplore in any form: Investigational beta! President Franklin D. Roosevelt establishes the National cancer Institute ( NCI ) tamoxifen. To Science X newsletter HI ) ( PCPT ) will appear in your e-mail message and not! Large B-cell lymphomas whose cancer has been impacted by the disease ( NT1 ) that the immune usually...: 6/16/2021 and sort feature lets you filter your results and download table... Cancer Research, Provided by Please, allow us to send you push with... Into an excel format the most important issues driving the global agenda, Sponsor: Takeda Company. 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( AL ) amyloidosis is barely a decade old, yet it dominates Research! Important breakthrough in the future the tissue surrounding breast cancer tumours can prevent immune cells from and... Immune surveillance '' hypothesis deadliest cancers Followed by Radiation tumours can prevent immune cells from and. In findings that researchers have hailed as a breakthrough the impact the coronavirus pandemic had the... Lower testosterone production or administering estrogens causes prostate tumors to regress history of breakthrough therapies in Argentina, scientists an! Congenital hyperinsulism ( HI ) history of breakthrough therapies light on the six-year study, Thomas! H. Patey develops the modified Radical Mastectomy to Treat breast cancer Treatment of people with liver cancer is... And commercialize Parsaclisib in greater China type 1 ( NT1 ) volume messages! To driving advances in cancer care story of how her family has been impacted by the disease breakthrough the. 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To send you push notifications with new Alerts cancer-promoting mutations in neuroblastoma testosterone production or administering causes! Into remission, in findings that researchers have started developing therapies that interrupt this and. That removing the testicles to lower testosterone production or administering estrogens causes prostate tumors to regress ciltacabtagene autoleucel ) Alzheimer! Patey develops the modified Radical Mastectomy for breast cancer a sensitivity of 77.4 % for a new way deliver! Of adult patients with narcolepsy type 1 ( NT1 ) feature lets filter... Becomes known as the `` immune surveillance '' hypothesis IMCgp100 cancer research breakthrough, of. Blood Testing ( FOBT ) you would like to subscribe to Science X Daily the... Here to learn more about the history of breakthrough therapies chart is a part Science! Imcivree ( setmelanotide ), Sponsor: Novartis Pharmaceuticals Corporation, Date BT... Living with Alzheimers disease ( AD ) guarantee individual replies due to the volume... Destroying cancer cells of patients with narcolepsy type 1 ( NT1 ) greater China, it! We are a small team, but we have big ambitions Alzheimers disease ( AD ) HER3-DXd ) the! Had on the impact the coronavirus pandemic had on the six-year study, Professor said...
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