But the synbiotic did improve gastrointestinal symptoms in participants and reduced autism severity as assessed by the Autism Treatment Evaluation Checklist (ATEC). The synbiotic also resulted in significant elevations in individual SCFA levels, significantly increased homovanillic acid, and significantly reduced serotonin, which were not observed in the placebo group. IBS patients are also at increased risk of depression, anxiety, bipolar, and sleep disorders.189 Both strains improved emotional well-being and social functioning, but participants consuming B. longum R0175 also reported increased energy levels that positively impacted their willingness and ability to perform everyday tasks. 2006;16(2):86-93. Bifidobacterium longum is a probiotic bacterium Torrazza RM, Ukhanova M, Wang X, Sharma R, Hudak ML, Neu J, Mai V. Intestinal microbial ecology and environmental factors affecting necrotizing enterocolitis. Grill J, Schneider F, Crociani J, Ballongue J. Purification and characterization of conjugated bile salt hydrolase from, Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links, Depression and other common mental disorders: global health estimates. Also, the authors cannot rule out if the maltodextrin administered to the placebo group (but not the synbiotic group) had an impact given that IBS severity significantly decreased from baseline in the placebo group after weeks 4 and 8 of the trial. Angurana SK, Bansal A, Singhi S, Aggarwal R, Jayashree M, Salaria M, Mangat NK. The relevant literature was obtained following a search in PubMed using the search terms Bifidobacterium longum; double-blind with the PubMed filters Randomized Controlled Trial; Clinical Trial., Some of the diseases can be categorized as non-communicable diseases (NCDs), linked with genetic, environmental, and lifestyle factors. Thus, NCDs are recognized as a significant challenge by the 2030 Agenda for Sustainable Development Goals,251 and a commitment has been made to reduce a third of premature mortality from NCDs through prevention and treatment.251 The trials presented suggest that B. longum administration alone or in combination with other bacterial species and prebiotics may have the potential to reduce severity of or prevent certain diseases, including NCDs, in early life, across adulthood and into old age. The authors state that the reductions in inflammatory markers observed in this trial would be indicative of clinical remission and a lower risk of relapse but larger patient numbers would be necessary to demonstrate clinical efficacy. However, the evidence to date suggests that continued research and investment into the beneficial properties of B. longum is worthwhile given that this species could serve to significantly improve several aspects of human health from birth and beyond. This is a probiotic supplement containing B. longum that I personally take and recommend: Custom Probiotics Five Strain Bifidobacteria. However, the lysate failed to improve skin barrier recovery rate. It produces lactic and acetic acid in the gut. In addition, the sample size of n=38 limited the statistical power. infantis suppressed proinflammatory IL-17 cytokine production and may be useful in the treatment of Th17-mediated diseases [41]. The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota. infantis exposure was associated with colonization with moderate numbers of Bifidobacteriaceae but the effect was most pronounced after gastric suction had ended and the strain was fed orally (as opposed to the twice-daily 1-h exposure of the gastric mucosa to the strain). However, the results of this pilot trial suggest that B. longum ssp. longum BB536, B. longum ssp. Xiao J, Kondo S, Yanagisawa N, Miyaji K, Enomoto K, Sakoda T, Iwatsuki K, Enomoto T. Dennis-Wall JC, Culpepper T, Nieves C, Rowe CC, Burns AM, Rusch CT, Federico A, Ukhanova M, Waugh S, Mai V, et al. 17-Mar-2023 at 10:36 GMT, Related tags Muoz JAM, Chenoll E, Casinos B, Bataller E, Ramn D, Genovs S, Montava R, Ribes JM, Buesa J, Fbrega J, et al. Probiotical S.p.A. developed an innovative range of probiotics (BifiZen) for mental wellbeing based on a high-potential probiotic combination of four Bartek | 28-Feb-2023 If you are considering creating your own website business, or if you have a brick-and-mortar business but want an online presence, I highly recommend SBI! Watch and find out how our effective, functional botanicals can give you an edge to create winning products that support consumers' health and wellness PROBIOTICAL | 01-Mar-2023 The formulation did not prevent moderate-to-severe diarrhea during treatment. Results from three large clinical trials show that the intake of yogurt containing Bifidobacterium longum can help relieve symptoms of allergy. Bercik P, Park AJ, Sinclair D, Khoshdel A, Lu J, Huang X, Deng Y, Blennerhassett PA, Fahnestock M, Moine D, et al. Information is shared for educational purposes only. Residents receiving bacterial strains had significantly more frequent bowel movements (without causing diarrhea) than those in the placebo group. Consuming B. longum BB536 for 10months alleviated the symptoms of upper respiratory illnesses in children aged 26y old in a parallel RDBPCT.94 Specifically, the strain was associated with a reduced duration of sore throat by 46% (p=0.018), runny nose by 15% (p=0.087), and cough by 16% (p=0.087) compared with the placebo. Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut. The mechanisms involved are not yet fully understood and vary from strain to strain but they can induce pro- or anti-inflammatory effects. Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ, Kerr C, Hourihane J, Murray D, Fuligni F, et al. The human colon is recognized as one of the most densely populated ecosystems on earth with the bacterial component reported to reach 1014 cells.1 These microorganisms are intricately linked to host physiology and health since they perform several essential functions with consequences not only for the gastrointestinal environment but also for remote organs of the body. In 2012, it was estimated that 1 in 160 children globally had a pervasive developmental disorder including an autism spectrum disorder (ASD).123 But the reported prevalence has since increased, and in Ireland alone, the prevalence rate for ASD in children was estimated at 1.5%.124 Comorbidities include gastrointestinal issues such as abdominal pain, constipation, and diarrhea.125 Wang et al.92 performed a RDBPCT in children with ASD to investigate the impact of a synbiotic formulation on ASD symptoms as well as gut microbiota composition, SCFA concentrations, and levels of neurotransmitters. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. A previous study found that growing B. longum B6 in lactose prior to treatment increased its ability to improve lactose digestion in sufferers as it induces higher -galactosidase activity in the strain.194. BB536 has been used as probiotic since its discovery for half a century and many studies have been conducted to clarify its effectiveness. , "These results suggest that there are cases in which Bifidobacteria do not colonize even with breastfeeding and that supplementation with B. infantis in the early postnatal period and either breastfeeding or supplementation of alternative breast milk components may be necessary to establish a high percentage of Bifidobacteria. . longum is a probiotic species that appears to be destined for use in humans. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. According to these researchers, the names would then be something like. Cryan JF, O Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, et al. To avoid adverse effects, talk to your doctor about whether probiotics could be appropriate for you. Smecuol E, Hwang HJ, Sugai E, et al. Test subjects also performed better at problem-solving as measured via the Coping Checklist CCL) (p<0.05). The formulation consisted of three different Bifidobacterium species, namely B. longum ssp. lactis MB 2409, and B. bifidum MB 109B. For the adaptive immune system, the balance of T-cell subsets Th1, Th2, Th17, and T regulatory cells [Tregs]) is critical to homeostasis.100,101, During pregnancy, a bias toward Th2 cells protects the fetus.102 Th2-type cytokines tend to produce an anti-inflammatory response.103 After birth, the development of the Th1 immune response (Th1-type cytokines tend to be pro-inflammatory)103 can reset the Th1/Th2 balance, and it is suggested that exposure to environmental microbes plays a critical role in this.89 In infants, high levels of circulating Th2-associated chemokines and low levels of Th1-chemokines have been associated with allergic disease and sensitization.104 Wu et al.89 investigated the impact of administering B. longum BB536 to healthy newborn infants on the immune response and intestinal microbiota over a 12-month period where interferon- (IF-) secretion cells were used to represent Th1 cytokines, and IL-4 secretion cells were used to represent Th2 cytokines. However, before the intervention took place, differences in fecal microbiota composition, SCFA production, and plasma neurotransmitters were investigated between children diagnosed with ASD and normal children. Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice, The gut-brain axis, BDNF, NMDA and CNS disorders. Heijtz RD, Wang S, Anuar F, Qian Y, Bjrkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S. Normal gut microbiota modulates brain development and behavior. Long-term colonization exceeding six years from early infancy of. Patients in the intervention group displayed significantly reduced IL-6 (p<0.001), TNF- (p=0.019), IL-5 (p=0.002), and endotoxin (p=0.007) by the end of treatment and significantly increased IL-10 levels (p=0.027) compared with placebo. Like other Bifidobacterium species, B. O Mahony L, McCarthy J, Kelly P, Hurley G, Luo F, Chen K, O Sullivan GC, Kiely B, Collins JK, Shanahan F, et al. Aaseth J, Skalny AV, Roos PM, Alexander J, Aschner M, Tinkov AA. Two formulations were assessed: B. longum BL999 with L. rhamnosus LPR and BL999 with L. paracasei ST11, and the infants were assessed for 24months. B. longum treatment significantly improved lung injury following infection and sepsis in mice. infantis M-63) and two B. breve strains (B. Twelve weeks of supplementation significantly reduced the abundance of inflammation-associated bacteria including Eubacterium, Clostridiales and Prevotellaceae. B. longum, like other Bifidobacteria, are on the European QPS (Qualifeid Presumptoion of Safety) list. The formulation contained B. longum A101, B. bifidum A218, B. catenulatum A302, and L. plantarum A87 and was administered to patients for 6months. A reduction in SCFA producers, including bifidobacteria, increased abundance of pathogens and facultative anaerobes, and a reduction in microbial diversity are recognized features of the elderly microbiome.227229. In hemodialysis patients, a synbiotic formulation proved even more effective than the bacterial formulation alone for significantly decreasing pro-inflammatory markers (C-reactive protein and IL-6), endotoxin levels, and anti-heat shock protein 70 antibodies compared with the placebo following 12weeks of intervention in a RDBPCT.172 Heat shock protein 70 protects cells from urea-induced damage.203 The synbiotics consisted of FOS, galactooligosaccharides (GOS), and inulin with B. longum LAF-5, B. lactis BIA 6, B. bifidum BIA 6, and L. acidophilus T16, while the bacterial formulation alone consisted of the same four strains. Furthermore, infants given the supplement had a reduction in the frequency of watery stools, in addition to a general reduction in defecation occurrences. High-density lipoprotein (HDL) cholesterol was also significantly reduced (p<0.01) by the BB536-containing fermented milk, which may increase the risk for CVDs, thus this formulation requires further testing and specific mechanisms of action need to be unraveled. Bifidobacterium longum (B. longum) is a type of probiotic ("good" bacteria) that lives in the intestines. longum BB536 (designated as BB536) is one of the well-established probiotic strains with numerous profound health benefits in humans (Xiao, 2009). A previous study had demonstrated the efficacy of 1010 CFU/ml of B. infantis 35624 for relieving IBS symptoms in patients when administered in a milk drink a response that was associated with a normalization of the anti-inflammatory to pro-inflammatory cytokine ratio.164 In capsule form, the 1010 CFU/ml of B. infantis 35624 coagulated into a glue-like mass which the authors state is due to the intense hygroscopic nature of the strain that presumably impacted its growth characteristics in the gut; but with time the higher formulation should lead to noticeable benefits as the bacterium replicates to the concentration required to achieve efficacy. Blood sera samples were analyzed for total antioxidative status (TAS) and de-proteinated whole blood, plasma, and erythrocyte lysate were analyzed for oxidized glutathione (GSSG) and reduced glutathione (GSH). TARC has been used in several studies to measure disease severity in atopic dermatitis.225 In a follow-on study, fecal samples of the trial participants were investigated for changes to the gut microbiota.183 Subjects suffering from Japanese cedar pollinosis had increased levels of Bacteroides fragilis compared with healthy subjects, but this increase was suppressed by B. longum BB536 treatment. infantis promoted the immune response in human volunteers [3]. Jacobs SE, Tobin JM, Opie GF, Donath S, Tabrizi SN, Pirotta M, Morley CJ, Garland SM, ProPrems Study Group . The synbiotic did not impact any of the measured clinical parameters including C-reactive protein, full blood counts, blood lipids, and levels of glucose, insulin, and immunoglobulins. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Cognitive function Numerous studies have shown that Bifidobacterium longum supplementation in patients suffering from ulcerative colitis, chronic fatigue syndrome and psoriasis resulted in a significant decrease in various inflammatory markers such as C-reactive protein, tumour necrosis factor and interleukin 1. In terms of immunity, NVP-1703 was associated with improved anti-allergic immunological profiles of participants by significantly increasing IL-10 levels (p=0.047), and significantly increasing the ratios of IL-10/IL-14 (p=0.046) and IL-10/IL-13 (p=0.018). Maternal & infant health For sufferers of perennial allergic rhinitis, 4 weeks of consuming the formulation NVP-1703 composed of B. longum IM55 and L. plantarum IM76 significantly reduced total nasal symptom scores at weeks 1, 3, and 4.186 It also significantly reduced rhinorrhea at weeks 1, 3, and 4, and numerically, but not statistically, reduced sneezing and nasal congestion over the 4 weeks. Exp Dermatol. Novanuit. Significant decrease in the Beck Depression Inventory; Significantly improved mood & sleep quality; IBS/Mild to moderate depression & anxiety, Alzheimers disease/Cognitive functions & Metabolic status. Nick Cassavetes ,60 yrs old
However, there were several limitations within this study due to the challenging nature of the study population. Available from: The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Chronically persistent eczema was reported in 26% of the placebo group but only in 10% of the BL999+LPR group (p=0.016) and 6% of the BL999+ST11 group (p=0.003). It is commonly found in adults and children Cao Y-N, Feng L-J, Wang B-M, Jiang K, Li S, Xu X, Wang W-Q, Zhao J-W, Wang Y-M. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY. However, the sample size of this crossover study was small at n=25, and the washout period was 15d, so a carryover effect of treatment cannot be ruled out. The bacterial strains B. longum BL04, L. fermentum LF16, L. rhamnosus LR06, and L. plantarum LP01 were reported to significantly improve mood and sleep quality, and reduce depressive mood state, anger, and fatigue in healthy volunteers in a RDBPCT.179 However, the trial consisted of 38 participants, thus larger scale trials are warranted to confirm these results. For further details of this trial, see Table 2. Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study. What proportion of symptomatic side effects in patients taking statins are genuinely caused by the drug? Martoni CJ, Evans M, Chow CE, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: a randomized controlled trial. In a mouse model, acetate produced in the gut by bifidobacteria has been shown to improve intestinal defenses and protect against infection.39 Acetate and lactate reduce the pH in the gut, which is believed to prevent microbiota imbalances and prevent pathogen growth.40,41 Indeed, Henrick et al.42 reported a trend for increasing fecal pH in breast-fed infants over the past century (from 5.0 to 6.5) that is associated with loss of specialized Bifidobacterium species and may pose increased risk for microbiota dysbiosis. The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis? Bienfaits de la prise de probiotiques . Fitz-Gibbon S, Tomida S, Chiu B-H, Nguyen L, Du C, Liu M, Elashoff D, Erfe MC, Loncaric A, Kim J, et al. The higher dose formulation proved less effective than the standard dose, highlighting again the importance of clinical data at different dosage levels. Psychological stress is known to contribute to several gastrointestinal dysfunctions through the brain-gut axis.195 The formulation Probio-Stick which contains B. longum Rosell-175 and L. acidophilus Rosell-52 proved effective in relieving stress-induced gastrointestinal symptoms in volunteers in a RDBPCT following 3weeks of intervention.168 Specifically, the formulation significantly reduced abdominal pain (p=0.004) and nausea/vomiting (p=0.009) in the volunteers who had been selected for the trial based on suffering from daily stress with at least two stress-induced symptoms in the previous month. The effect of probiotics on serum levels of cytokine and endotoxin in peritoneal dialysis patients: a randomised, double-blind, placebo-controlled trial. Following this, the researchers aimed to continue the research and establish the potential benefits of B. infantis M-63 alone administered to full-term infants. Only one strain, B. longum CCFM681, proved capable of alleviating colitis by inhibiting pro-inflammatory pathways, protecting the intestinal mechanical barrier, and modulating the gut microbiota. Early evidence suggests that it may also suppress allergies, reduce cholesterol, and improve skin health. Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study. The ePub format is best viewed in the iBooks reader. Indeed, Ivanov et al.56 reported that serpin from B. longum effectively inhibited eukaryotic elastase-like proteases, leading them to speculate on its role in immunomodulation given that elastase is released at sites of intestinal inflammation by activated neutrophils. Research into the beneficial properties of B. longum has unveiled a range of mechanisms, including the production of bioactive molecules, such as short-chain fatty acids, polysaccharides, and serine protease inhibitors. It was also associated with significantly reduced serum hs-CRP (p=0.02) and increased plasma levels of the antioxidant glutathione (p=0.03). Bifidobacterium longum BB536, originally isolated from a healthy infant, is a clinically effective, well-established, multifunctional probiotic that has a long history of human use in alleviating gastrointestinal, immunological, and infectious diseases ( 8 ). However, it had no impact on lipid profiles, serum insulin, uric acid, and total antioxidant capacity. B. longum ssp. We believe that the most accurate information is found directly in the scientific source. Paller A, Jaworski JC, Simpson EL, Boguniewicz M, Russell JJ, Block JK, Tofte S, Dunn JD, Feldman SR, Clark AR, et al. In addition, the impacts of GOS and 2-FL, individually and combined, on the outgrowth of fecal bifidobacteria at (sub)species level was investigated . For further details of these trials, see Table 3. Throughout the study period, the proportion of participants in the intervention group reporting adequate relief from IBS symptoms was significantly higher than that in the placebo group (p<0.05); however, the formulation failed to induce superior effects on individual symptoms including abdominal pain. Cross-contamination between the two groups in the hospital setting could also have impacted the results where the control group may have acquired strains from the formulation, although this was not assessed in the study. Bifidobacteria are important intestinal bacteria that provide a variety of health benefits in infants. Objectives: The aim of our study was to analyse the antibiotic susceptibility of various strains of Bifidobacterium spp. Odamaki T, Kato K, Sugahara H, Hashikura N, Takahashi S, Xiao J-Z, Abe F, Osawa R. Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study. National Heart, Lung, and Blood Institute. Effects of Selenium supplementation in patients with mild cognitive impairment or alzheimers disease: a systematic review and meta-analysis. 4.5/5 10 valuations . Fedorak RN, Feagan BG, Hotte N, Leddin D, Dieleman LA, Petrunia DM, Enns R, Bitton A, Chiba N, Par P, et al. B. longum ssp. These levels were further enhanced with a greater frequency of breastfeeding, highlighting the possible compatibility of the species with breast milk. Bercik P, Verdu EF, Foster JA, Macri J, Potter M, Huang X, Malinowski P, Jackson W, Blennerhassett P, Neufeld KA, et al. * Notre mlange unique est conu pour aider promouvoir la sant digestive et peut aider apaiser les problmes digestifs courants, comme les maux d'estomac, les gaz . Effects of synbiotic fermented milk containing. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. As a result, there has been increased discussion around administering probiotics to neonates to achieve the formation of a Bifidobacterium-dominant microbiota, with previous studies highlighting anti-inflammatory and growth promotion effects as well as prevention of associated conditions in at-risk infants. Disclaimer: Please note: By law, I cannot provide any personalized recommendations for your specific health concern on this site. Gagn en Sant Gatineau, Outaouais. Duration of intensive care unit (ICU) stay was also reduced in the VSL#3 group compared with placebo (6.5d versus 9). However, at the end of treatment or during the 2 weeks after treatment, 35% of the standard dose group experienced less of the moderate-to-severe diarrhea compared with only 17% in the placebo group (p=0.04). Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. Biljana received her PhD from Hokkaido University. medical concerns you may have. Significantly reduced duration of diarrhoea (by 1.2 d); Resolution of abdominal pain in significantly higher number of children; Significant efficacy for inducing & maintaining remission. Probiotic Generating an ePub file may take a long time, please be patient. Ehrlich AM, Pacheco AR, Henrick BM, Taft D, Xu G, Huda MN, Mishchuk D, Goodson ML, Slupsky C, Barile D, et al. breve M-16V proved effective for significantly relieving nasal symptoms of allergic rhinitis (nasal itching, nasal obstruction, sneezing, rhinorrhea, and itchy eyes; p<0.005) and improving quality of life (p<0.001) in children suffering from seasonal allergic rhinitis and intermittent asthma due to pollen.95 However, the small sample size used in this trial (n=40) suggests that further trials with larger participant numbers are needed to confirm the findings. Thus, further studies are warranted in animals and humans to decipher the bacterial formulations, duration, and dosage regimens that generate physiologically meaningful reductions in LDL and total cholesterol. Beneficially modulated the gut microbiota; Significantly increased nave, activated memory, regulatory T cells, B cells, & NK cells & decreased memory T cells, Healthy elderly/Cognitive function, Body composition, & Bowel habits, Healthy elderly/Cognition, Mood, & Intestinal health. However, the 12-week intervention period is potentially too short a longer period may reveal changes in some of the cognitive functions for which no significant improvements were noted. I hav
Likewise, significant differences were observed in the 536 group from baseline to week 8 for the Rachmilewitz endoscopic index and the Mayo subscore but not in the placebo group. . more products. Gut health Three weeks of consuming a formulation consisting of B. longum MM2, B. bifidum G91, and L. gasseri KS-13 maintained CD4+ lymphocytes in elderly subjects and was associated with significantly increased IL-10 levels (p<0.0001) compared with placebo, resulting in a less inflammatory cytokine profile in a crossover RDPCT.235 However, the crossover nature of the study was associated with limitations. Available from: Cholesterol Treatment Trialists Collaboration CTT), Fulcher J, O Connell R, Voysey M, Emberson J, Blackwell L, Mihaylova B, Simes J, Collins R, Kirby A, Colhoun H, et al. In combination with a low-dose prodrug of a conventional IBD treatment (balsalazide), VSL#3 proved significantly superior to conventional treatments alone (balsalazide or 5-aminosalicylic acid [5-ASA]) for obtaining remission in patients with active mild-to-moderate UC following 8 weeks of treatment.155 In patients with relapsing UC and receiving conventional 5-ASA treatment and/or immunosuppressants, VSL#3 treatment for 8 weeks was associated with significantly improved UC disease activity index scores compared with placebo (p=0.01), improved rectal bleeding, and the formulation tended to induce remission in relapsing patients.156 As a sole treatment for mild-to-moderate active UC, VSL#3 resulted in significantly higher patient numbers with improved UC disease activity index scores following 6weeks of administration compared with placebo (32.5 versus 10%, respectively, p=0.001), and after 12weeks of treatment, 42.9% of patients in receipt of VSL#3 achieved remission compared with 15.7% in the placebo group (p<0.001).157 The formulation proved less effective for preventing CD recurrence, however, in patients following surgery in a multicentre RDBPCT following 90d of treatment.158 However, the low rate of recurrence in the placebo group rendered this trial underpowered to observe statistical differences. 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