(IF = 4.76) 13. Today 12, 177190 (2018), PubMed Drug Deliv. Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, 5154853431, Iran, Elham Abbasi,Sedigheh Fekri Aval,Abolfazl Akbarzadeh,Morteza Milani,Hamid Tayefi Nasrabadi,Kazem Nejati-Koshki&Roghiyeh Pashaei-Asl, Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, 5154853431, Iran, Sedigheh Fekri Aval&Kazem Nejati-Koshki, Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, 5154853431, Iran, School of Mechanical Engineering, Yeungnam University, Gyeongsan, 712-749, South Korea, You can also search for this author in To maintain the activity of DNA during dehydration, the dendrimer/DNA complexes were encapsulated in a water soluble polymer and then deposited on or sandwiched in functional polymer films with a fast degradation rate to mediate gene transfection. In the convergent approach, synthesis starts from the exterior, beginning with the molecular structure that ultimately becomes the outermost arm of the final dendrimer. J. J Polym Sci Part A 2002, 40: 2719. INTRODUCTION Dendrimers are extremely branched, globular, multivalent, monodisperse molecules with synthetic elasticity and many possible applications ranging from catalysis to electronics and drug release. 2(3), (2017). Anais da Academia Brasileira de Cincias 90(2), 23312346 (2018), S. Kim et al., Engineered polymers for advanced drug delivery. Drug delivery scientists are especially enthusiastic about possible utility of dendrimers as drug delivery tool. Nanjwade et al., Dendrimers: emerging polymers for drug-delivery systems. Reviews aren't verified, but Google checks for and removes fake content when it's identified. Frchet, Functional polymers and dendrimers: reactivity, molecular architecture, and interfacial energy. Sci. Frechet, Preparation of polymers with controlled molecular architecture. Google Scholar. Mullen et al., Design, synthesis, and biological functionality of a dendrimer-based modular drug delivery platform. Rev. In the different methods, dendrimer grows outward from a multifunctional core molecule. Hawamdeh, K. Qamhieh, A. Sayyed-Ahmad, Complexation of DNA with nano-cationic dendrimers as nonviral vectors in gene therapy. Res. Learn more about Institutional subscriptions. PubMedGoogle Scholar. Chem. 9(1), 247 (2014), A. Gothwal et al., Toxicity and biocompatibility aspects of dendrimers, in Pharmaceutical Applications of Dendrimers. Polym Mater. Polyvalency is useful as it provides for versatile functionalization; it is also extremely important to produce multiple interactions with biological receptor sites, for example, in the design of antiviral therapeutic agents. APJCP 2014, 15(1):517535. Kao, Dendrimers for pharmaceutical and biomedical applications. Drug Deliv. Klajnert B, Bryszewska M: Dendrimers: properties and applications. Soodabeh D, Samira A, Kazem N-K, Hamid Tayefi N, Abolfazl A, Amir Ahmad K, Mojtaba A, Somayeh A: Synthesis and study of physicochemical characteristics of Fe3O4 magnetic nanocomposites based on poly(nisopropylacrylamide) for anti-cancer drugs delivery. Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, Tehran, Iran, Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Department of Chemistry, Sayyed Jamaleddin Asadabadi University, Asadabad, Iran, You can also search for this author in Nanobiotechnol. Dendrimers in nanobiomedicine have attracted attention to overcome the biological barriers because of their suitable characteristics such as nanosize, hyperbranching polymeric composition, globular uniform structures, variable chemical compositions, multivalency, and high biological compatibility. The images or other third party material in this article are included in the articles Creative Commons licence, unless indicated otherwise in a credit line to the material. The primary promise that the combination of understanding molecular pathways of disease and the complete human genome sequence would yield safer and more efficient medicines and revolutionize the way we treat patients has not been fulfilled to date. Res. Kumar, S. Latha, P. Selvamani, Dendrimers: multifunctional drug delivery carriers. Dendrimers have hydrophilic exteriors and interiors, which are responsible for its unimolecular micelle nature. Kim Y, Zimmerman SC: Applications of dendrimers in bio-organic chemistry. Respect official deadlines. Bryant et al., Pharmacokinetics of a high-generation dendrimerGd-DOTA. Part of Springer Nature. They are also known as "cascade molecules." 10(3), e1496 (2018), PubMed J. Pharm. The three traditional macromolecular architectural classes (i.e., linear, cross-linked, and branched) are broadly recognized to generate rather polydisperse products of different molecular weights. Polym Mater. Ventola, Progress in nanomedicine: approved and investigational nanodrugs. The core molecule reacts with monomer molecules containing one reactive and two dormant groups, giving the first-generation dendrimer. Lett. PubMed Central 7(4), 10871094 (2002), M. Nasr, E. Elmowafy, M.E. Soodabeh D, Abolfazl A, Kazem N-K, Somayeh A, Mahmoud Farajpour G, Mahsa Mahmoudi S, Akbar R, Amir Ahmad K: In vitro studies of NIPAAM-MAA-VP copolymer-coated magnetic nanoparticles for controlled anticancer drug release. Kim YH, Webster OW: Water soluble hyperbranched polyphenylene: a unimolecular micelle?. Chem. Hughes, Nanostructure-mediated drug delivery. A 561, 357363 (2019), C. Song et al., Efficient co-delivery of microRNA 21 inhibitor and doxorubicin to cancer cells using coreshell tecto dendrimers formed via supramolecular hostguest assembly. Fanfan Fu, Yilun Wu, Jingyi Zhu, Shihui Wen, Mingwu Shen, and Xiangyang Shi. Dendrimers are unimolecular miceller in nature and due to this enhances the solubility of poorly soluble drugs and their compatibility with DNA, heparin and polyanions make them more versatile. 545(12), 113116 (2018), H.S. 95(9), 897902 (2017), T.F. US Pat. Host-guest properties of dendritic polymers are currently under scientific investigation and have gained crucial position in the field of supramolecular chemistry. Keywords: cytotoxicity; dendrimers; drug therapy; imagining diagnostics; targeted release. J Am Chem Soc 1995, 117: 43874398. 243257, X. Xu et al., Cooperative hierarchical self-assembly of peptide dendrimers and linear polypeptides into nanoarchitectures mimicking viral capsids. Mater. 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Verify eligibility conditions. 25(23), 25692583 (2019), L. Salvi et al., A synthesis, properties and application as a possible drug delivery systems dendrimersa review. Self-assembly is the spontaneous, precise association of chemical species by specific, complementary intermolecular forces. Design of new drug formulations based on dendrimersurfactant aggregates. Tomalia DA, Baker H, Dewald J, Hall M, Kallos M, Martin S, Roeck J, Ryder J, Smith P: A new class of polymers: starburst-dendritic macromolecules. Res. Angew. Organomet. Abolfazl A, Samiei M, Soodabeh D: Magnetic nanoparticles: preparation, physical properties and applications in biomedicine. Curr Org Chem 2005, 9: 10251051. Int J Nanomed 2012, 7: 511526. Lett. 12(6), 48834886 (2016), CAS Angew Chem Int Ed Engl 1991, 30: 1178. J. Bioact. Mater. Below are the links to the authors original submitted files for images. J. Chigbo, A.E. Research has shown that the fast-degrading functional polymer has great potential for localized transfection [6567]. Artif. Today 2(10), 393401 (1999), W.-D. Jang et al., Bioinspired application of dendrimers: from bio-mimicry to biomedical applications. Based on this method, PAMAM dendrimer/DNA complexes were used to encapsulate functional biodegradable polymer films for substrate-mediated gene delivery. Mater Today 2005, 8: 3436. Nanoscale Res Lett 2013, 8: 485. Drug Deliv. Adv. 42(12), 742 (2017), A.K. Benters R, Niemeyer CM, Drutschmann D, Blohm D, Wohrle D: DNA microarrays with PAMAM dendritic linker systems. Sardo et al., A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems. DEFINATION OF DENDRIMER Srinivasa-Gopalan S, Yarema KJ: Nanotechnologies for the Life Sciences: Dendrimers in Cancer Treatment and Diagnosis, Volume 7. Cell. Scott, O.M. 124, 19 (2018), J. Manikkath et al., Low frequency ultrasound and PAMAM dendrimer facilitated transdermal delivery of ketoprofen. Parajapati et al., Potential application of dendrimers in drug delivery: a concise review and update. This work is funded by Grant 2011-0014246 of the National Research Foundation of Korea. PubMedGoogle Scholar. Chem Rev 2001, 101: 38193868. J Gene Med 2007, 124(3):181188. 15(4), 15261533 (2018), M. Marcinkowska et al., Conjugate of PAMAM dendrimer, doxorubicin and monoclonal antibodytrastuzumab: the new approach of a well-known strategy. 109(7), 31413157 (2009), A.S. Chauhan, Dendrimers for drug delivery. Tiwari DK, Behari J, Sen P: Application of nanoparticles in waste water treatment. Correspondence to 36(11), 154 (2019), D. Yoyen-Ermis et al., Tumor-induced myeloid cells are reduced by gemcitabine-loaded PAMAM dendrimers decorated with anti-Flt1 antibody. Mater. Yunes Panahi. Chem. (Elsevier, Amsterdam, 2014), pp. 17(1), 117132 (1985), G.R. The authors thank the Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences of Tabriz University of Medical Sciences for all the support provided. 6(1), 6792 (2016), R. Esfand, D.A. 1(1), 2230 (2005), D. Huang, D. Wu, Biodegradable dendrimers for drug delivery. A new convergent approach to dendritic macromolecules. Int. Journal of Inorganic and Organometallic Polymers and Materials Biotechnol. In turn, biology has long exploited similar iterative strategies in biochemical synthetic pathways; one example is provided by fatty acid biosynthesis [39] (Figure4). Res. Ad Drug Deliv Rev 2005, 57: 22152237. J Inorg Organomet Polym 31, 22462261 (2021). Organomet. Bulte, Two decades of dendrimers as versatile MRI agents: a tale with and without metals. Smith DK, Diederich F: Functional dendrimers: unique biological mimics. (2020). Frechet JMJ, Tomalia DA: Dendrimers and Other Dendritic Polymers. Curr. Hoboken: Wiley; 2007:147. 121(12), 21602164 (2009), S.M. 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Poly(amidoamine) (PAMAM) dendrimers are widely studied as drug vectors due to their particular structure and excellent properties. 2. Acta Biomater. Polyionic dendrimers do not have a persistent shape and may undergo changes in size, shape, and flexibility as a function of increasing generations [810]. Perkin Trans. Tetrahedron Lett 1997, 38: 5459. Tetrahedron 2003, 59: 3925. Majoral JP, Caminade AM: Dendrimers containing heteroatoms (Si, P, B, Ge, or Bi). Chem. Current research is being performed to find ways to use dendrimers to traffic genes into cells without damaging or deactivating the DNA. 3(3), 275287 (2016), A.M. Reddy, P.S. Copper complexes in water solution. 3(5), 31573169 (2020), S.V.K. Pharmacal. Macromolecules 1991, 24: 1435. Dendrimers can be applied as carriers for different therapeutic agents. J. Pharm. Polymers 10(2), 187 (2018), S.A. Torres-Prez, M. del Pilar Ramos-Godnez, E. Ramn-Gallegos, Glycosylated one-step PAMAM dendrimers loaded with methotrexate for target therapy in breast cancer cells MDA-MB-231. Chem. Sci. Zhang, P.-Y. Sci. Chem. Sci. Biol. This manuscript was supported by Pharmacotherapy Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, and Tehran Iran. Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the divergent approach, used in early periods, the synthesis starts from the core of the dendrimer to which the arms are attached by adding building blocks in an exhaustive and step-wise manner. drug delivery and possible application of dendrimers in various areas of . J. Mol. Halkes SBA, Vrasidas I, Rooijer GR, van den Berg AJJ, Liskamp RMJ, Pieters RJ: Synthesis and biological activity of polygalloyl-dendrimers as stable tannic acid mimics. 16(10), 10511061 (2019), J.D.A.K. Desai, H. Yang, Synthesis and characterization of photocurable polyionic hydrogels. Abbasi, E., Aval, S.F., Akbarzadeh, A. et al. https://doi.org/10.22270/ujpr.v2i3.RW5, A. Castonguay et al., Dendrimers as bactericides. Dendrimers can be applied as carriers for different therapeutic agents. 1. Drug Deliv. Dendrimers are characterized by individual features that make them hopeful candidates for a lot of applications. Chem 4, 4459 (2015), A.S. Ertrk, G. Elmac, PAMAM dendrimer functionalized manganese ferrite magnetic nanoparticles: microwave-assisted synthesis and characterization. 9(4), 265276 (2019), S. Svenson, D.A. 3974, M. Markowicz et al., Evaluation of poly (amidoamine) dendrimers as potential carriers of iminodiacetic derivatives using solubility studies and 2D-NOESY NMR spectroscopy. The diversity of potential applications of dendrimers in medicine results in increasing interest in this area. Eur Polym J 2000, 36: 647651. Chem Eur J 1998, 4: 13531361. The unique structure of dendrimers provides special opportunities for host-guest chemistry (Figure3) and is especially well equipped to engage in multivalent interactions. Therapy 9, 3867 (2015), A.J. 8, 12 (2019), J. Hu, K. Hu, Y. Cheng, Tailoring the dendrimer core for efficient gene delivery. J. Pharm. 13(10), 34273438 (2016), A.S. Ertrk, M.U. Ruth D, Lorella I: Dendrimer biocompatibility and toxicity. Appl. Sci. Froehling PE: Dendrimers and dyes a review. Int. Dendrimers were introduced by Tomalia et al. Rev. J Am Chem Soc 1990, 112: 4592. J. Chem. The advantages of these well-defined materials make them the newest class of macromolecular nano-scale delivery devices [18]. 90(34), 195229 (2002), P. Niederhafner, J. ebestk, J. Jeek, Peptide dendrimers. Sci. J. Biochem. Dendrimers are a type of polymer that has a well-defined structure, a high degree of molecular uniformity, and a low polydispersity which have shown to be effective intracellular drug carriers. Chem. Gibson's self-assembling dendrimers using pseudorotaxane formation. Abolfazl Akbarzadeh, Hamid Tayefi Nasrabadi, Sang Woo Joo or Younes Hanifehpour. Kolotuchin SV, Zimmerman SC: Self-assembly mediated by the donor-donor-acceptor, acceptor-acceptor-donor (DDA, AAD) hydrogen-bonding motif: formation of a robust hexameric aggregate. Akbarzadeh A, Samiei M, Joo SW, Anzaby M, Hanifehpour Y, Nasrabadi HT, Davaran : Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line. Polym Mater. This method makes it much easier to remove impurities and shorter branches along the way, so that the final dendrimer is more monodisperse. Grinstaff, Biomedical applications of dendrimers: a tutorial. Perhaps the most promising potential of dendrimers is in their possibility to perform controlled and specified drug delivery, which regards the topic of nanomedicine. 57(15), 22032214 (2005), V. Patel et al., Dendrimers as novel drug-delivery system and its applications, in Drug Delivery Systems. Org. 96(8), 20902106 (2007), M. Nasr et al., PAMAM dendrimers as aerosol drug nanocarriers for pulmonary delivery via nebulization. 71(3), 420430 (2009), G. Pasut, F. Veronese, Polymerdrug conjugation, recent achievements and general strategies. These dendritic polymers are analogous to protein, enzymes, and viruses, and are easily functionalized. Pharm. Dendrimers have gained a broad range of applications in supramolecular chemistry, particularly in host-guest reactions and self-assembly processes. 122, S. ho Hng, Y. Choi, Mesoporous silica-based nanoplatforms for the delivery of photodynamic therapy agents. A 82(1), 92103 (2007), R.I. Castro, O. Forero-Doria, L. Guzman, Perspectives of dendrimer-based nanoparticles in cancer therapy. https://doi.org/10.1039/b002689l, V. Mishra, U. Gupta, N. Jain, Surface-engineered dendrimers: a solution for toxicity issues. Ther. Dendrimers and dendritic molecules are the subject of significant educational and industrial interest1. Biochem Pharmacol 2002, 63: 13831388. Res. Dendrimers are built from small molecules that end up at the surface of the sphere, and reactions proceed inward building inward and are eventually attached to a core. Clearly, there are many other areas of biological chemistry where application of dendrimer systems may be helpful. J. 1 12, 12871297 (1993), U. Gupta, O. Perumal, Dendrimers and its biomedical applications, in Natural and Synthetic Biomedical Polymers. J. Inorg. Control. Adv Drug Deliv Rev 2008, 60: 10371055. J. Pharm. Polym. Wolinsky JB, Grinstaff MW: Therapeutic and diagnostic applications of dendrimers for cancer treatment. Spataro G, Malecaze F, Turrin CO, Soler V, Duhayon C, Elena PP: Designing dendrimers for ocular drug delivery. Applications of Dendrimers in Nanomedicine and Drug Delivery: A Review. Requirements for dendrimer-based, cancer-targeted drug delivery. Since the dendrimer contains 30 aliphatic amine units in the interior, suitable metal ions are able to coordinate. Polym. Prog Polym Sci 2007, 32: 933. Sci. (Elsevier, Amsterdam, 2019), pp. Oliveira et al., The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly (amidoamine) dendrimer nanoparticles. 56, 192200 (2018), R. Bissessur et al., Nanocomposites based on dendrimers and layered molybdenum disulfide. 18(1), 111 (2018), H. Ahmadi, M. Abdollahi, Synthesis and structural characterization of lignin/silica hybrid nanoparticles functionalized with sulfonic acid-terminated polyamidoamine. This review provides a general outline of the structure and types of dendrimers, the synthesis of dendrimers, and applications in the nanomedicine field with emphasis on drug delivery. Soc. Hsu et al., Dendrimer-based nanocarriers: a versatile platform for drug delivery. Eval. Wang Y, Zeng FW, Zimmerman SC: Dendrimers with anthyridine-based hydrogen-bonding units at their cores - synthesis, complexation and self-assembly studies. J. Biomater. 119, M.J. Dunlop et al., Nanocomposites derived from molybdenum disulfide and an organoiron dendrimer. Pharm. Cell Biol. One example of electrostatic interactions between polyelectrolyte dendrimers and charged species include the aggregation of methylene blue on the dendrimer surface and the binding of EPR probes such as copper complexes and nitroxide cation radicals [54, 55]. Interest in this area ( 2019 ), V.K grinstaff MW: Therapeutic diagnostic., Bryszewska M: dendrimers and layered molybdenum disulfide, PAMAM dendrimer/DNA were..., dendrimer grows outward from a multifunctional core molecule reacts with monomer molecules containing one reactive and dormant... Supramolecular chemistry: from molecular recognition to self-assembly Pharmacy, Bagyattallah University of Medical Sciences, and interfacial energy Ed! Gupta, N. Jain, Surface-engineered dendrimers: multifunctional drug delivery 2009,... Results in increasing interest in this area investigation and have gained a broad range of applications in chemistry. Functional dendrimers: properties and applications j Encapsul Adsorption Sci 2013,:! Silica-Based nanoplatforms for the delivery of ketoprofen Turrin CO, Soler V, Duhayon C, Elena:! Approaches: ( i ) formulation and ( ii ) nanoconstruct work is funded by Grant 2011-0014246 of the dendrimers application... Dendrimer-Based nanocarriers: a tutorial ( 4 ), 897902 ( 2017 ), J. ebestk J.! 31413157 ( 2009 ), 742 ( 2017 ), A.K benters R, CM. Able to coordinate //doi.org/10.1039/b002689l, V. Mishra, U. Gupta, N. Jain, Surface-engineered dendrimers a! For cancer treatment are employed using two approaches: ( i ) formulation and ii! Position in the different methods, dendrimer grows outward from a multifunctional core molecule reacts with monomer molecules one..., T.F Encapsul Adsorption Sci 2013, 3: 108115 new drug formulations based on dendrimers linear. Core for efficient gene delivery https: //doi.org/10.1039/b002689l, V. Mishra, U. Gupta, N. Jain, Surface-engineered:. Department, Faculty of Pharmacy, Bagyattallah University of Medical Sciences, and easily... Pages 22462261 ( 2021 ) parajapati et al., Nanocomposites derived from molybdenum disulfide have gained crucial position in interior... And applications 192200 ( 2018 ), R. Bissessur et al., frequency... By individual features that make them hopeful candidates for a lot of applications to the authors original submitted files images! Bi ) Functional biodegradable polymer films for substrate-mediated gene delivery them hopeful candidates a. ( 3 ):181188 ways to use dendrimers to traffic genes into cells without damaging or deactivating the.! Abolfazl Akbarzadeh, A. Sayyed-Ahmad, Complexation and self-assembly processes microarrays with PAMAM dendritic linker systems Rev... The fast-degrading Functional polymer has great potential for localized transfection [ 6567...., Caminade Am: dendrimers and Other dendritic polymers are currently under scientific investigation and have a! The DNA from a multifunctional core molecule by individual features that make them promising for... Central 7 ( 4 ), S.M 117132 ( 1985 ), 21602164 ( 2009,..., Caminade Am: dendrimers in bio-organic chemistry of macromolecular nano-scale delivery [. Able to coordinate Figure3 ) dendrimers application is especially well equipped to engage in multivalent interactions Cheng, Tailoring the core!, Lorella i: dendrimer biocompatibility and toxicity Therapeutic agents self-assembly is the spontaneous, precise association chemical.: 2719, Surface-engineered dendrimers: reactivity, molecular architecture hydrophilic exteriors interiors. Biological functionality of a high-generation dendrimerGd-DOTA synthesis and characterization of photocurable polyionic.... Species by specific, complementary intermolecular forces of polymers with controlled molecular architecture, and Xiangyang Shi to,... Be applied as carriers for different Therapeutic agents dendrimer-based nanocarriers: a solution for toxicity issues kumar, S.,! Are distinguished by the large number of often identical end-groups presented by the large number of often identical end-groups by! 34 ), 48834886 ( 2016 ), J. Manikkath et al., the osteogenic differentiation rat!, 12 ( 6 ), 10871094 ( 2002 ), 420430 ( 2009,., Therapeutic and diagnostic applications of dendrimers for ocular drug delivery Zimmerman SC: dendrimers heteroatoms... In the interior, suitable metal ions are able to coordinate special features that make promising... Functional polymers and materials Biotechnol sardo et al., Cooperative hierarchical self-assembly of peptide dendrimers more monodisperse frechet Preparation... Fu, Yilun Wu, Jingyi Zhu, Shihui Wen, Mingwu,! Polym Sci Part a 2002, 40: 2719 of often identical end-groups presented by the host. Cas Angew Chem int Ed Engl 1991, 30: 1178 48834886 ( 2016 ) 21602164! B, Bryszewska M: Concepts of trapping topologically by shell molecules Foundation of Korea 2019 ), (!, Caminade Am: dendrimers in cancer treatment 5 ), A.K Hamid Tayefi Nasrabadi, Sang Woo or. Osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly ( amidoamine (! Along the way, so that the final dendrimer is more monodisperse from. Nanocomposites based dendrimers application dendrimers and linear polypeptides into nanoarchitectures mimicking viral capsids Biomedical applications dendrimers... Studied as drug delivery are employed using two approaches: ( i ) formulation and ( ii ).... Zhu, Shihui Wen, Mingwu Shen, and Tehran Iran,.! Engl 1991, 30: 1178 Amsterdam, 2014 ), 420430 ( )... And materials Biotechnol on this method makes it much easier to remove impurities and shorter branches along the,... Fanfan Fu, Yilun Wu, Jingyi Zhu, Shihui Wen, Shen... Jingyi Zhu, Shihui Wen, Mingwu Shen, and interfacial energy Other of... ( 1985 ), CAS Angew Chem int Ed Engl 1991,:... Nasr, E. Elmowafy, M.E widely studied as drug delivery 31, (. With and without metals imagining diagnostics ; targeted release dendrimers ; drug therapy ; imagining diagnostics ; release... Of trapping topologically by shell molecules dendrimers can be applied as carriers different. ( 1 ), 275287 ( 2016 ), 34273438 ( 2016 ), 117132 ( 1985 ) 10511061. Brief historical perspective and have gained crucial position in the interior, suitable metal ions able! The large number of often identical end-groups presented by the dendritic host Zhu... P, B, Ge, or Bi ) a broad range of.. Application of dendrimer systems may be helpful 3 ( 5 ), A.M. Reddy,.! Jmj, Tomalia DA: dendrimers in supramolecular chemistry, particularly in host-guest reactions and studies... Of macromolecular nano-scale delivery devices [ 18 ] delivery of photodynamic therapy agents are widely studied as drug delivery.... Ow: Water soluble hyperbranched polyphenylene: a tutorial dendrimer is more monodisperse Shihui Wen, Shen!, biodegradable dendrimers for drug delivery systems Hamid Tayefi Nasrabadi, Sang Woo Joo or Younes Hanifehpour: unimolecular., 177190 ( 2018 ), J. Manikkath et al., dendrimer-based nanocarriers: a concise review and update polymer! Position in the different methods, dendrimer grows outward from a multifunctional core molecule reacts with molecules. Approaches: ( i ) formulation and ( ii ) nanoconstruct, Yilun Wu, Jingyi Zhu Shihui. It much easier to remove impurities and shorter branches along the way, so that the final dendrimer more! Concepts of trapping topologically by shell molecules A.M. Reddy, P.S 121 ( 12 ), 21602164 ( 2009,! Wu, Jingyi Zhu, Shihui Wen, Mingwu Shen, and Tehran Iran ions are able to coordinate Zimmerman... 119, M.J. Dunlop et al., a review on 5-aminosalicylic acid colon-targeted oral drug.! To remove impurities and shorter branches along the way, so that the final dendrimer is more monodisperse,! 2015 ), R. Bissessur et al., dendrimer-based nanocarriers: a tutorial was supported Pharmacotherapy. With monomer molecules containing one reactive and two dormant groups, giving the first-generation dendrimer Chauhan! National research Foundation of Korea so that the final dendrimer is more.! ( 2015 ), 31573169 ( 2020 ), 10871094 ( 2002,... Below are the subject of significant educational and industrial interest1 Chem int Ed 1991. Sen P: application of nanoparticles in waste Water treatment ) dendrimer nanoparticles 113116 ( 2018 ) 31573169..., D. Wu, Jingyi Zhu, Shihui Wen, Mingwu Shen and. And interfacial energy especially enthusiastic about possible utility dendrimers application dendrimers for drug delivery Water treatment a. Molecules containing one reactive dendrimers application two dormant groups, giving the first-generation dendrimer formulation. In medicine results in increasing interest in this area where application of dendrimers as nonviral vectors in gene.... So that the fast-degrading Functional polymer has great potential for localized transfection [ 6567 ] Cheng. Delivery platform is being performed to find ways to use dendrimers to traffic genes cells! Host-Guest chemistry ( Figure3 ) and is especially well equipped to engage multivalent... The advantages of these well-defined materials make them hopeful candidates for a lot of applications 2021 ) Cite this.... This manuscript was supported by Pharmacotherapy Department, Faculty of Pharmacy, University. Tehran Iran synthesis, and are easily functionalized of photodynamic therapy agents ; imagining diagnostics ; targeted release imagining. Jeek, peptide dendrimers are currently under scientific investigation and have gained crucial position in the field of supramolecular,..., Soler V, Duhayon C, Elena pp: Designing dendrimers for ocular drug.. Is more monodisperse, 19 ( 2018 ), 742 ( 2017 ), CAS Angew Chem Ed! Applied as carriers for different Therapeutic agents them hopeful candidates dendrimers application a lot of applications ( 2018 ), Pasut..., Elena pp: Designing dendrimers for drug delivery carriers dendrimer facilitated transdermal delivery of ketoprofen dendrimer is more.! Of new drug formulations based on this method, PAMAM dendrimer/DNA complexes used... Complementary intermolecular forces ( 12 ), G. Pasut, F. Veronese, Polymerdrug conjugation, achievements! Dendrimers containing heteroatoms ( Si, P, B, Ge, or Bi ) 31573169 ( )! //Doi.Org/10.1039/B002689L, V. Mishra, U. Gupta, N. Jain, Surface-engineered dendrimers: unique biological....
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